1/6/2024 0 Comments Elucidate syThe international journal of neuropsychopharmacology. Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice. Dominguez-Lopez S, Piccart E, Lynch W B, Wollet M B, Sharpe A, Beckstead M J. The purpose of this study is to elucidate the association between PM2.5 and. Movement disorders : official journal of the Movement Disorder Society. Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson's model. Lynch W B, Tschumi C W, Sharpe A, Branch S Y, Chen C, Ge G, Li S, Beckstead M J. A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. BoIFLHo, S.Y., GoLDSTEIN, A.M., MARTINEz, E. Tschumi C W, Daszkowski A W, Trzeciak M, Sharpe A, Beckstead M J. secretion is formed and to elucidate whether the isotonic fluid transport in the acinar cells. Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia. Chucair-Elliott A, Ocanas S R, Stanford D R, Ansere V A, Buettner K B, Porter H, Eliason N L, Reid J J, Sharpe A, Stout M B, Beckstead M J, Miller B F, Richardson A, Freeman W M. Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Sharpe A L, Trzeciak M, Eliason N L, Blankenship H, Byrd B, Douglas P, Freeman W M, Beckstead M J. The long-term goals of our lab are to 1) elucidate the pharmacology and neurocircuitry involved in the regulation of appetite for and consumption of rewards (both food and drug), and 2) to determine the contribution of hypothalamic neuropeptides to age-related conditions such as obesity and cognitive decline.ġ. We are interested in the normal physiological role for these neuropeptides, as well as the adaptations that occur in this neurocircuitry under the conditions of obesity, food restriction, and chronic drug use. We use behavioral (operant conditioning), anatomical, pharmacological, and molecular approaches to address our research questions, often in combination with genetic mouse models. Taken together, our results support an intricate control of cell survival/death modulated by oxidative stress, apoptosis and autophagy in synthetic cathinones-induced renal injury.Email Sharpe lab is interested in understanding the contribution of neuropeptides such as proopiomelanocortin, neurotensin, and corticotropin releasing factor to addiction, obesity, and age-related cognitive impairment, and in the development of therapeutics to treat these conditions. Importantly, these antioxidant agents significantly aggravated renal cell death induced by cathinone derivatives, most likely due to their autophagy-blocking properties. Functional and proteinprotein interaction network analysis of colorectal cancer induced by ulcerative colitis. Both drugs triggered a rise in reactive oxygen and nitrogen species formation, which was completely prevented by antioxidant treatment with N‑acetyl‑L‑cysteine or ascorbic acid. Moreover, the autophagy inhibitor 3-methyladenine significantly potentiated cell death, indicating that autophagy may serve as a cell survival mechanism that protects renal cells against synthetic cathinones toxicity. Both drugs elicited apoptotic cell death and prompted the formation of acidic vesicular organelles and autophagosomes in HK-2 cells. Search Methodology About The Monitor Powered by. FinCrime Risk Monitor Methodology About The Monitor Powered by. 3,4-DMMC and methylone were selected to further elucidate the mechanisms behind synthetic cathinones-induced cell death. The Elucidate FinCrime Risk Monitor is the largest public database for financial crime risk and evaluates more than 21000 banks performance. We also have projects using vibrational spectroscopy for the elucidation of. All four derivatives elicited cell death in a concentration- and time-dependent manner, in the following order of potency: 3,4-DMMC > MDPV > methylone ≈ pentedrone. In this study, the potential in vitro nephrotoxic effects of four commonly abused cathinone derivatives, namely pentedrone, 3,4-dimethylmethcatinone (3,4-DMMC), methylone and 3,4-methylenedioxypyrovalerone (MDPV), were assessed in the human kidney HK-2 cell line. Kidney injury has been reported in intoxications associated with synthetic cathinones, but the molecular mechanisms involved have not been explored yet. Synthetic cathinones abuse remains a serious public health problem.
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